课题组简介：

生物大分子的结构与功能/分子病毒学课题组聚焦高致病性RNA病毒以及与人类重大疾病、重要生理功能相关的蛋白质机器的结构与功能研究。课题组综合运用生物化学、分子生物学、生物物理、结构生物学和细胞生物学等多学科技术手段，解析高致病性非分节负链RNA病毒的RNA合成机器，阐明其分子机制与调控机理；揭示膜蛋白复合物介导跨膜运输的分子基础，并结合结构药理学探究抗病毒药物及小分子调控剂的作用机制，为抗病毒药物研发及相关人类疾病的机制探索在分子水平上提供理论依据与结构基础。

课题组照片：

课题组负责人：茹衡

课题组成员

教师：茹衡

硕士研究生：方宇航、陈潘祎、施依慧、李宁馨     

主要研究方向

1. 高致病性接触传播的非分段负链RNA病毒（nsNSV）RNA合成及其调控的分子机制；核苷酸类似物及非核苷酸类似物抑制剂与病毒RNA合成机器的构效关系；宿主因子调控病毒RNA合成机器的分子机制；

2. 与人类重大疾病和重要生理功能相关的膜蛋白复合物结构与功能的关系，包括膜受体、酶、离子通道、转运蛋白及跨膜调控功能蛋白的激活、抑制、信号转导等精细机制；膜蛋白与小分子抑制剂、激活剂的构效关系。

代表性成果：

1. Du Tianjiao*, Jiening Wang*, Chengji Yang*, Rubing Xue, Ying Chen, Kaiyue Jie, Xiaokang Zhang, Long Zhang, Gaojie Song, Qiansen Zhang#, Shan Wu#, Heng Ru#. Structural insights into Measles virus RNA synthesis regulation and pan-paramyxoviral polymerase inhibition by ERDRP-0519. Proceedings of the National Academy of Sciences of the United States of America. 2026 Apr 14;123(15):e2522978123.

2. Rihong Zhao*, Tianjiao Du*, Yalu Ji, Zhuolu Ren, Shanshan Jiang, Heng Ru#, Jingmin Gu#. Characterization of the phage ΦK64 depolymerase S2-4 and its therapeutic effect against K1 serotype Klebsiella pneumoniae. Microbiological Research. 2026 Feb 13:307:128475.

3. Guobao Li*, Tianjiao Du*, Jiening Wang*, Kaiyue Jie, Zhuolu Re, Xiaokang Zhang, Long Zhang, Shan Wu#, Heng Ru#. Structural insights into the RNA-dependent RNA polymerase complexes from highly pathogenic Marburg and Ebola viruses. Nature Communications. 2025 Mar 31;16(1):3080.

4. Yitong Ma*, Yijie Wang*, Mengyuan Tang*, Yuan Weng, Ying Chen, Yueming Xu, Shuxiao An, Yiran Wu, Suwen Zhao, Huanhuan Xu, Dali Li, Mingyao Liu, Weiqiang Lu#, Heng Ru#, Gaojie Song#. Cryo-EM structure of an activated GPR4-Gs signaling complex. Nature Communications. 2025 Jan 11;16(1):605.

5. Wenxia Liu*, Mengyuan Tang*, Jiening Wang*, Fangfang Wang, Gaojie Song, Xiaokang Zhang#, Shan Wu#, Heng Ru#. Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1. Cell Discovery. 2024 Feb; 20;10(1):21.

6.  Heng Ru#, Pengfei Zhang and Hao Wu#. Structural gymnastics of RAG-mediated DNA cleavage in V(D)J recombination. Current Opinion in Structural Biology. 2018 Dec; 53: 178-186.

7.  Heng Ru*, Wei Mi*, Pengfei Zhang, David G. Schatz, Maofu Liao#, Hao Wu#. DNA Melting Initiates the RAG Catalytic Pathway. Nature Structural and Molecular Biology. 2018 Aug; 25(8): 732-742.

8. Heng Ru, Melissa G. Chambers, Tian-Min Fu, Alexander B. Tong, Maofu Liao#, Hao Wu#. Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell. 2015 Nov 19; 163(5): 1138-52.

9. Heng Ru*, Xiangmin Ni*, Lixia Zhao*, Christopher Crowley, Wei Ding, Li-Wei Hung, Neil Shaw, Genhong Cheng#, Zhi-Jie Liu#. Structural basis for termination of AIM2-mediated signaling by p202. Cell Research. 2013 Jun; 23(6): 855-8.

10. Songying Ouyang*, Xianqiang Song*, Yaya Wang*, Heng Ru*, Neil Shaw, Yan Jiang, Fengfeng Niu, Yanping Zhu, Weicheng Qiu, Kislay Parvatiyar, Yang Li, Rongguang Zhang, Genhong Cheng#, Zhi-Jie Liu#. Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity. 2012 Jun 29; 36(6): 1073-86.

*co-first authors

#(co-)correspondence authors

更新时间2026年9月